Evaluation of Pharmacokinetic Feasibility of Febuxostat/L-pyroglutamic Acid Cocrystals in Rats and Mice

• मुख्य लेखकों: Jeong-Eun Yu (लेखक), Byoung Hoon You (लेखक), Mingoo Bae (लेखक), Seung Yon Han (लेखक), Kiwon Jung (लेखक), Young Hee Choi (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-08-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Febuxostat (FBX), a selective xanthine oxidase inhibitor, belongs to BCS class II, showing low solubility and high permeability with a moderate <i>F</i> value (<49%). Recently, FBX/L-pyroglutamic acid cocrystal (FBX-PG) was developed with an improving 4-fold increase of FBX solubility...