Novel positive allosteric modulators of A2B adenosine receptor acting as bone mineralisation promoters

• Main Authors: Elisabetta Barresi (Author), Chiara Giacomelli (Author), Laura Marchetti (Author), Emma Baglini (Author), Silvia Salerno (Author), Giovanni Greco (Author), Federico Da Settimo (Author), Claudia Martini (Author), Maria Letizia Trincavelli (Author), Sabrina Taliani (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Small-molecules acting as positive allosteric modulators (PAMs) of the A2B adenosine receptor (A2B AR) could potentially represent a novel therapeutic strategy for pathological conditions characterised by altered bone homeostasis, including osteoporosis. We investigated a library of compounds (4-13)...