Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

• Main Authors: Zephania Kwong Glover (Author), Aaron Wecksler (Author), Baikuntha Aryal (Author), Shrenik Mehta (Author), Melissa Pegues (Author), Wayman Chan (Author), Mari Lehtimaki (Author), Allen Luo (Author), Alavattam Sreedhara (Author), V. Ashutosh Rao (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Biotherapeutics are exposed to common transition metal ions such as Cu(II) and Fe(II) during manufacturing processes and storage. IgG1 biotherapeutics are vulnerable to reactive oxygen species (ROS) generated via metal-catalyzed oxidation reactions. Exposure to these metal ions can lead to potential...