Gene amplification and point mutations in pyrimidine metabolic genes in 5-fluorouracil resistant Leishmania infantum.

• Asıl Yazarlar: Jean-François Ritt (Yazar), Frédéric Raymond (Yazar), Philippe Leprohon (Yazar), Danielle Légaré (Yazar), Jacques Corbeil (Yazar), Marc Ouellette (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2013-11-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The human protozoan parasites Leishmania are prototrophic for pyrimidines with the ability of both de novo biosynthesis and uptake of pyrimidines.Five independent L. infantum mutants were selected for resistance to the pyrimidine analogue 5-fluorouracil (5-FU) in the hope to better understand the me...