Enhancement of oral bioavailability and anti-Parkinsonian efficacy of resveratrol through a nanocrystal formulation

• Main Authors: Sha Xiong (Author), Wei Liu (Author), Yile Zhou (Author), Yousheng Mo (Author), Yao Liu (Author), Xiaojia Chen (Author), Huafeng Pan (Author), Dongsheng Yuan (Author), Qi Wang (Author), Tongkai Chen (Author)
• Format: Book
• Published: Elsevier, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Resveratrol (RES), a non-flavonoid polyphenol extracted from a wide variety of plants, exhibits neuroprotective activities against Parkinson's disease (PD). However, undesirable water solubility of RES reduces its oral bioavailability and demonstrates low efficacy in blood and brain, thus limit...