Fragment-based virtual screening identifies novel leads against Plasmepsin IX (PlmIX) of Plasmodium falciparum: Homology modeling, molecular docking, and simulation approaches

• Автори: Haider Thaer Abdulhameed Almuqdadi (Автор), Sumaiya Kifayat (Автор), Razique Anwer (Автор), Jihad Alrehaili (Автор), Mohammad Abid (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2024-05-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Despite continuous efforts to develop safer and efficient medications, malaria remains a major threat posing great challenges for new drug discovery. The emerging drug resistance, increased toxicities, and impoverished pharmacokinetic profiles exhibited by conventional drugs have hindered the search...