The role of osmolarity adjusting agents in the regulation of encapsulated cell behavior to provide a safer and more predictable delivery of therapeutics

• Main Authors: Ainhoa Gonzalez-Pujana (Author), Aitor Rementeria (Author), Francisco Javier Blanco (Author), Manoli Igartua (Author), Jose Luis Pedraz (Author), Edorta Santos-Vizcaino (Author), Rosa Maria Hernandez (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Transplantation of cells within alginate microspheres has been extensively studied for sustained drug delivery. However, the lack of control over cell behavior represents a major concern regarding the efficacy and the safety of the therapy. Here, we demonstrated that when formulating the biosystem,...