PD149163 induces hypothermia to protect against brain injury in acute cerebral ischemic rats

• Main Authors: Teng-Fei Xue (Author), Xu Ding (Author), Juan Ji (Author), Hui Yan (Author), Ji-Ye Huang (Author), Xu-Dong Guo (Author), Jin Yang (Author), Xiu-Lan Sun (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Therapeutic hypothermia is a promising strategy for acute cerebral ischemia via physical or pharmacological methods. In this study, we pharmacologically induced hypothermia on Sprague Dawley rats by intraperitoneally injecting PD149163. We found that mild hypothermia was induced by PD149163 treatmen...