Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

• Main Authors: Mubarak A. Alamri (Author), Muhammad Tahir ul Qamar (Author), Muhammad Usman Mirza (Author), Safar M. Alqahtani (Author), Matheus Froeyen (Author), Ling-Ling Chen (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The papain-like protease (PLpro) is vital for the replication of coronaviruses (CoVs), as well as for escaping innate-immune responses of the host. Hence, it has emerged as an attractive antiviral drug-target. In this study, computational approaches were employed, mainly the structure-based virtual...