Discovery of human coronaviruses pan-papain-like protease inhibitors using computational approaches

• Asıl Yazarlar: Mubarak A. Alamri (Yazar), Muhammad Tahir ul Qamar (Yazar), Muhammad Usman Mirza (Yazar), Safar M. Alqahtani (Yazar), Matheus Froeyen (Yazar), Ling-Ling Chen (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2020-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The papain-like protease (PLpro) is vital for the replication of coronaviruses (CoVs), as well as for escaping innate-immune responses of the host. Hence, it has emerged as an attractive antiviral drug-target. In this study, computational approaches were employed, mainly the structure-based virtual...