Melatonin Reverses the Loss of Stemness Induced by TNF-α in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression

• मुख्य लेखकों: Xudong Wang (लेखक), Tongzhou Liang (लेखक), Jincheng Qiu (लेखक), Xianjian Qiu (लेखक), Bo Gao (लेखक), Wenjie Gao (लेखक), Chengjie Lian (लेखक), Taiqiu Chen (लेखक), Yuanxin Zhu (लेखक), Anjing Liang (लेखक), Peiqiang Su (लेखक), Yan Peng (लेखक), Dongsheng Huang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Hindawi Limited, 2019-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro culture results in loss of MSC stemness. The inflammation that occurs at stem cell transplant sites (such as that resulting from TNF-α) is a contributing factor for stem...