Melatonin Reverses the Loss of Stemness Induced by TNF-α in Human Bone Marrow Mesenchymal Stem Cells through Upregulation of YAP Expression

• Main Authors: Xudong Wang (Author), Tongzhou Liang (Author), Jincheng Qiu (Author), Xianjian Qiu (Author), Bo Gao (Author), Wenjie Gao (Author), Chengjie Lian (Author), Taiqiu Chen (Author), Yuanxin Zhu (Author), Anjing Liang (Author), Peiqiang Su (Author), Yan Peng (Author), Dongsheng Huang (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mesenchymal stem cells (MSCs) are promising candidates for tissue regeneration and disease treatment. However, long-term in vitro culture results in loss of MSC stemness. The inflammation that occurs at stem cell transplant sites (such as that resulting from TNF-α) is a contributing factor for stem...