Rule of five violations among the FDA-approved small molecule protein kinase inhibitors
Because genetic alterations including mutations, overexpression, translocations, and dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this enzyme family is the target of many drug discovery programs in the pharmaceutical industry. Overall, the US FDA has approved...
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Elsevier,
2023-05-01T00:00:00Z.
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