Amoxicillin Haptenation of α-Enolase is Modulated by Active Site Occupancy and Acetylation

• Egile Nagusiak: Juan M. González-Morena (Egilea), Francisco J. Sánchez-Gómez (Egilea), Yolanda Vida (Egilea), Ezequiel Pérez-Inestrosa (Egilea), María Salas (Egilea), María I. Montañez (Egilea), Alessandra Altomare (Egilea), Giancarlo Aldini (Egilea), María A. Pajares (Egilea), Dolores Pérez-Sala (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Allergic reactions to antibiotics are a major concern in the clinic. ß-lactam antibiotics are the class most frequently reported to cause hypersensitivity reactions. One of the mechanisms involved in this outcome is the modification of proteins by covalent binding of the drug (haptenation). Hence, i...