Enhancing the Oral Bioavailability of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers: In Vitro Characterization and Absorption in Rats after Oral Administration

Enhancing the Oral Bioavailability of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers: In Vitro Characterization and Absorption in Rats after Oral Administration

Candesartan Cilexetil (CC) is a prodrug widely used in the treatment of hypertension and heart failure, but it has some limitations, such as very poor aqueous solubility, high affinity to P-glycoprotein efflux mechanism, and hepatic first-pass metabolism. Therefore, it has very low oral bioavailabil...

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Main Authors: Walid Anwar (Author), Hamdy M. Dawaba (Author), Mohsen I. Afouna (Author), Ahmed M. Samy (Author), Mohammed H. Rashed (Author), Abdelaziz E. Abdelaziz (Author)
Format: Book
Published: MDPI AG, 2020-10-01T00:00:00Z.
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