Enhancing the Oral Bioavailability of Candesartan Cilexetil Loaded Nanostructured Lipid Carriers: In Vitro Characterization and Absorption in Rats after Oral Administration

• Asıl Yazarlar: Walid Anwar (Yazar), Hamdy M. Dawaba (Yazar), Mohsen I. Afouna (Yazar), Ahmed M. Samy (Yazar), Mohammed H. Rashed (Yazar), Abdelaziz E. Abdelaziz (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Candesartan Cilexetil (CC) is a prodrug widely used in the treatment of hypertension and heart failure, but it has some limitations, such as very poor aqueous solubility, high affinity to P-glycoprotein efflux mechanism, and hepatic first-pass metabolism. Therefore, it has very low oral bioavailabil...