NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway

• Main Authors: Wenjiao Wang (Author), Tao Xu (Author), Xinyue Chen (Author), Kemeng Dong (Author), Chunkai Du (Author), Jing Sun (Author), Cuige Shi (Author), Xiaoxiao Li (Author), Yutao Yang (Author), Hui Li (Author), Zhi-Qing David Xu (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Accumulated evidences show that neuroinflammation play a pivotal role in the pathogenesis of depression. Neuropeptide Y (NPY) and its receptors have been demonstrated to have anti-inflammative as well as antidepressant effects. In the present study, the ability of NPY to modulate depressive-like beh...