Butyrate Enhances Desensitization Induced by Oral Immunotherapy in Cow's Milk Allergic Mice

• Main Authors: Marlotte M. Vonk (Author), Bart R. J. Blokhuis (Author), Mara A. P. Diks (Author), Laura Wagenaar (Author), Joost J. Smit (Author), Raymond H. H. Pieters (Author), Johan Garssen (Author), Léon M. J. Knippels (Author), Betty C. A. M. van Esch (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. In previous studies, we showed that a fructo-oligosaccharide- (FOS-) supplemented diet enhanced oral immunotherapy (OIT) efficacy in a mouse model for cow's milk allergy. Fermentation of FOS by intestinal bacteria leads to production of short-chain fatty acids (SCFA) including butyr...