An mRNA vaccine elicits STING-dependent antitumor immune responses

• Main Authors: Zhe Chen (Author), Chaoyang Meng (Author), Junhua Mai (Author), Yongbin Liu (Author), Hangwen Li (Author), Haifa Shen (Author)
• Format: Book
• Published: Elsevier, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid-formulated RNA vaccines have been widely used for disease prevention and treatment, yet their mechanism of action and individual components contributing to such actions remain to be delineated. Here, we show that a therapeutic cancer vaccine composed of a protamine/mRNA core and a lipid shell...