Hypoxia-stressed cardiomyocytes promote early cardiac differentiation of cardiac stem cells through HIF-1α/Jagged1/Notch1 signaling

• Main Authors: Keke Wang (Author), Ranran Ding (Author), Yanping Ha (Author), Yanan Jia (Author), Xiaomin Liao (Author), Sisi Wang (Author), Rujia Li (Author), Zhihua Shen (Author), Hui Xiong (Author), Junli Guo (Author), Wei Jie (Author)
• Format: Book
• Published: Elsevier, 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia is beneficial for the differentiation of stem cells transplanted for myocardial injury, but mechanisms underlying this benefit remain unsolved. Here, we report the impact of hypoxia-induced Jagged1 expression in cardiomyocytes (CMs) for driving the differentiation of cardiac stem cells (CSCs...