Caspase-11 mediated inflammasome activation in macrophages by systemic infection of A. actinomycetemcomitans exacerbates arthritis

• Main Authors: Tokuju Okano (Author), Hiroshi Ashida (Author), Noriko Komatsu (Author), Masayuki Tsukasaki (Author), Tamako Iida (Author), Marie Iwasawa (Author), Yuto Takahashi (Author), Yasuo Takeuchi (Author), Takanori Iwata (Author), Miwa Sasai (Author), Masahiro Yamamoto (Author), Hiroshi Takayanagi (Author), Toshihiko Suzuki (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Clinical studies have shown that Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) is associated with aggressive periodontitis and can potentially trigger or exacerbate rheumatoid arthritis (RA). However, the mechanism is poorly understood. Here, we show that systemic infecti...