Narrowing the Gap Between In Vitro and In Vivo Genetic Profiles by Deconvoluting Toxicogenomic Data In Silico

• Main Authors: Yuan Liu (Author), Runyu Jing (Author), Zhining Wen (Author), Menglong Li (Author)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2020-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Toxicogenomics (TGx) is a powerful method to evaluate toxicity and is widely used in both in vivo and in vitro assays. For in vivo TGx, reduction, refinement, and replacement represent the unremitting pursuit of live-animal tests, but in vitro assays, as alternatives, usually demonstrate poor correl...