Synthesis and in vitro evaluation of benzo[b]thiophene-3-carboxylic acid 1,1-dioxide derivatives as anticancer agents targeting the RhoA/ROCK pathway

• Автори: Jinhao Liang (Автор), Jin Huang (Автор), Jianzhan Yang (Автор), Weihong Liang (Автор), Haoxiang Li (Автор), Yunshan Wu (Автор), Bo Liu (Автор)
• Формат: Книга
• Опубліковано: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Rho family GTPases regulate cellular processes and promote tumour growth and metastasis; thus, RhoA is a potential target for tumour metastasis inhibition. However, limited progress has been made in the development of RhoA targeting anticancer drugs. Here, we synthesised benzo[b]thiophene-3-carboxyl...