TGFβ level in healthy and children with Marfan syndrome-effective reduction under sartan therapy

• Main Authors: Veronika C. Stark (Author), Jakob Olfe (Author), Daniel Diaz-Gil (Author), Yskert von Kodolitsch (Author), Rainer Kozlik-Feldmann (Author), Johannes Reincke (Author), Maria Stark (Author), Peter Wiegand (Author), Tanja Zeller (Author), Thomas S. Mir (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionTransforming growth factor β (TGFβ) metabolism plays an important role in the pathogenesis of Marfan syndrome (MFS). Accordingly, drug therapy uses TGFβ receptor blockade to slow down the cardiovascular manifestations, above all aortic root dilatation. Angiotensin II type 1 receptor bloc...