CRISPR/Cas9 RET Gene Knockout in Medullary Thyroid Carcinoma Cell-lines: Optimization and Validation

• 主要な著者: Marjan Zarif-Yeganeh (著者), Dariush D Farhud (著者), Azam Rahimpour (著者), Sara Sheikholeslami (著者), Setareh Shivaei (著者), Mehdi Hedayati (著者)
• フォーマット: 図書
• 出版事項: Tehran University of Medical Sciences, 2022-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Background: Medullary Thyroid Cancer (MTC) is a very aggressive type of thyroid carcinoma. Mutation in RET proto-oncogene is demonstrated in MTC development. We aimed to knock-out of RET-oncogene using CRISPR/Cas9 genome editing method in MTC cell-lines. Methods: This research was conducted in Shahi...