Controlling the Mdm2-Mdmx-p53 Circuit

• मुख्य लेखकों: David L. Waning (लेखक), Jason A. Lehman (लेखक), Christopher N. Batuello (लेखक), Lindsey D. Mayo (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2010-05-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The p53 tumor suppressor is a key protein in maintaining the integrity of the genome by inducing either cell cycle arrest or apoptosis following cellular stress signals. Two human family members, Mdm2 and Mdmx, are primarily responsible for inactivating p53 transcription and targeting p53 protein fo...