Model‐based evaluation of image‐guided fractionated whole‐brain radiation therapy in pediatric diffuse intrinsic pontine glioma xenografts

• Main Authors: Hillary R. Husband (Author), Olivia Campagne (Author), Chen He (Author), Xiaoyan Zhu (Author), Brandon M. Bianski (Author), Suzanne J. Baker (Author), Anang A. Shelat (Author), Christopher L. Tinkle (Author), Clinton F. Stewart (Author)
• Format: Book
• Published: Wiley, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Radiation therapy (RT) is currently the standard treatment for diffuse intrinsic pontine glioma (DIPG), the most common cause of death in children with brain cancer. A pharmacodynamic model was developed to describe the radiation‐induced tumor shrinkage and overall survival in mice bearing...