Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity

• Автори: Kai Cheng (Автор), Cao Li (Автор), Jiachuan Jin (Автор), Xuezhen Qian (Автор), Jiayin Guo (Автор), Limini Shen (Автор), YiChen Dai (Автор), Xue Zhang (Автор), Zhanwei Li (Автор), Yichun Guan (Автор), Fei Zhou (Автор), Jin Tang (Автор), Jun Zhang (Автор), Bin Shen (Автор), Xin Lou (Автор)
• Формат: Книга
• Опубліковано: Elsevier, 2023-12-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach their full potential. To overcome this sequence-co...