Engineering RsDddA as mitochondrial base editor with wide target compatibility and enhanced activity

• Main Authors: Kai Cheng (Author), Cao Li (Author), Jiachuan Jin (Author), Xuezhen Qian (Author), Jiayin Guo (Author), Limini Shen (Author), YiChen Dai (Author), Xue Zhang (Author), Zhanwei Li (Author), Yichun Guan (Author), Fei Zhou (Author), Jin Tang (Author), Jun Zhang (Author), Bin Shen (Author), Xin Lou (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Double-stranded DNA-specific cytidine deaminase (DddA) base editors hold great promise for applications in bio-medical research, medicine, and biotechnology. Strict sequence preference on spacing region presents a challenge for DddA editors to reach their full potential. To overcome this sequence-co...