Chemotherapy and Immune Checkpoint Inhibitors in a Case of SMARCA4-dUT: A Case Report and Review of Literature

• Prif Awduron: Akriti Pokhrel MD (Awdur), Ruchi Yadav MD (Awdur), Kapil Kumar Manvar MD (Awdur), Richard Wu MD (Awdur), Vijay Jaswani MD (Awdur), Carrie Brooke Wasserman MD (Awdur), Jen C. Wang MD (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: SAGE Publishing, 2023-06-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

SMARCA4-deficient undifferentiated tumors (SMARCA4-dUT) are infrequently occurring aggressive neoplasms found predominantly in young male smokers. These tumors are distinguished by the loss of expression of Brahma-related gene 1 (BRG1) due to a deactivating mutation of SMARCA4. Immunophenotype can b...