Decrease of Prolylcarboxypeptidase Dose of Aqueous Humor is Involved in the Pathogenesis of Primary Open-Angle Glaucoma via Finetuning of the Local Ocular Renin-Angiotensin System

• Main Authors: Jing Ren (Author), Yuanyuan Xiao (Author), Di Wang (Author), Huiling Cui (Author), Rumeng Zhao (Author), Zilu Guo (Author), Yuhao Wang (Author), Shichao Zhu (Author), Bo Tang (Author), Jing Wang (Author), Gang Wang (Author), Huaying Wang (Author), Xinyuan Hu (Author), Rick F. Thorne (Author), Shichao Duan (Author), Haijun Li (Author)
• Format: Book
• Published: SAGE Publishing, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective In this study, we investigated the cause of the AngII dose elevation in aqueous humor of primary open-angle glaucoma (POAG) patients. Methods Enzyme-linked immunosorbent assay (ELISA), western blotting were used to detect concentration of Angiotensin Converting Enzyme 2 (ACE2) and Prolylca...