Direct and enhanced delivery of nanoliposomes of anti schizophrenic agent to the brain through nasal route

• Main Authors: Pratik Upadhyay (Author), Jatin Trivedi (Author), Kilambi Pundarikakshudu (Author), Navin Sheth (Author)
• 格式: 图书
• 出版: Elsevier, 2017-03-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

The problem of inadequate oral bioavailability of Quetiapine Fumarate, a lipophilic drug used for schizophrenia, due to hepatic metabolism and repulsion by brain barrier was attempted in this study. Combination of two approaches, viz. Quetiapine inclusion into the liposomal carrier for better diffus...