o-Vanillin binds covalently to MAL/TIRAP Lys-210 but independently inhibits TLR2

• Main Authors: Md. Habibur Rahaman (Author), Sara J. Thygesen (Author), Michael J. Maxwell (Author), Hyoyoung Kim (Author), Prerna Mudai (Author), Jeffrey D. Nanson (Author), Xinying Jia (Author), Parimala R. Vajjhala (Author), Andrew Hedger (Author), Irina Vetter (Author), Thomas Haselhorst (Author), Avril A. B. Robertson (Author), Brian Dymock (Author), Thomas Ve (Author), Mehdi Mobli (Author), Katryn J. Stacey (Author), Bostjan Kobe (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractToll-like receptor (TLR) innate immunity signalling protects against pathogens, but excessive or prolonged signalling contributes to a range of inflammatory conditions. Structural information on the TLR cytoplasmic TIR (Toll/interleukin-1 receptor) domains and the downstream adaptor proteins...