IK1 Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats

• Main Authors: Qing-Hua Liu (Author), Xi Qiao (Author), Li-Jun Zhang (Author), Jin Wang (Author), Li Zhang (Author), Xu-Wen Zhai (Author), Xiao-Ze Ren (Author), Yu Li (Author), Xiao-Na Cao (Author), Qi-Long Feng (Author), Ji-Min Cao (Author), Bo-Wei Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intracellular Ca2+ overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (IK1) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of IK1 currents is a compensation fo...