IK1 Channel Agonist Zacopride Alleviates Cardiac Hypertrophy and Failure via Alterations in Calcium Dyshomeostasis and Electrical Remodeling in Rats

• Үндсэн зохиолчид: Qing-Hua Liu (Зохиогч), Xi Qiao (Зохиогч), Li-Jun Zhang (Зохиогч), Jin Wang (Зохиогч), Li Zhang (Зохиогч), Xu-Wen Zhai (Зохиогч), Xiao-Ze Ren (Зохиогч), Yu Li (Зохиогч), Xiao-Na Cao (Зохиогч), Qi-Long Feng (Зохиогч), Ji-Min Cao (Зохиогч), Bo-Wei Wu (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Intracellular Ca2+ overload, prolongation of the action potential duration (APD), and downregulation of inward rectifier potassium (IK1) channel are hallmarks of electrical remodeling in cardiac hypertrophy and heart failure (HF). We hypothesized that enhancement of IK1 currents is a compensation fo...