Insulin Resistance and Pellino-1 Mediated Decrease in the Activities of Vasodilator Signaling Contributes to Sunitinib-Induced Hypertension

• Главные авторы: Yang Liu (Автор), Liang-Liang Tang (Автор), Chen Liang (Автор), Ming-Ming Wu (Автор), Zhi-Ren Zhang (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Предметы: article
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Antiangiogenic tyrosine kinases inhibitors induce hypertension, which may increase the incidents of cardiovascular complications and limit their use. However, the mechanisms by which usage of TKIs results in hypertension have not been fully understood. Here, we report the potential mechanisms of how...