Physical Factors Affecting Plasmid DNA Compaction in Stearylamine-Containing Nanoemulsions Intended for Gene Delivery

• Main Authors: Eryvaldo Socrates Tabosa do Egito (Author), Francisco Alexandrino (Author), Lourena Mafra Verissimo (Author), Lucymara Fassarella Agnez-Lima (Author), Lucila Carmem Monte Egito (Author), André Leandro Silva (Author), Anselmo Gomes de Oliveira (Author)
• Format: Book
• Published: MDPI AG, 2012-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cationic lipids have been used in the development of non-viral gene delivery systems as lipoplexes. Stearylamine, a cationic lipid that presents a primary amine group when in solution, is able to compact genetic material by electrostatic interactions. In dispersed systems such as nanoemulsions this...