Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

• Główni autorzy: Rachael Mooney (Autor), Asma Abdul Majid (Autor), Daniel Mota (Autor), Adam He (Autor), Soraya Aramburo (Autor), Linda Flores (Autor), Jennifer Covello-Batalla (Autor), Diana Machado (Autor), Joanna Gonzaga (Autor), Karen S. Aboody (Autor)
• Format: Książka
• Wydane: Hindawi Limited, 2018-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Tumor-tropic neural stem cells (NSCs) can be engineered to localize gene therapies to invasive brain tumors. However, like other stem cell-based therapies, survival of therapeutic NSCs after transplantation is currently suboptimal. One approach to prolonging cell survival is to transiently overexpre...