Bcl-2 Overexpression Improves Survival and Efficacy of Neural Stem Cell-Mediated Enzyme Prodrug Therapy

• Main Authors: Rachael Mooney (Author), Asma Abdul Majid (Author), Daniel Mota (Author), Adam He (Author), Soraya Aramburo (Author), Linda Flores (Author), Jennifer Covello-Batalla (Author), Diana Machado (Author), Joanna Gonzaga (Author), Karen S. Aboody (Author)
• Format: Book
• Published: Hindawi Limited, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor-tropic neural stem cells (NSCs) can be engineered to localize gene therapies to invasive brain tumors. However, like other stem cell-based therapies, survival of therapeutic NSCs after transplantation is currently suboptimal. One approach to prolonging cell survival is to transiently overexpre...