Use of microminipigs for unveiling unknown mechanisms of azithromycin-induced cardiovascular death

• Main Authors: Ai Goto (Author), Mihoko Hagiwara-Nagasawa (Author), Hiroko Izumi-Nakaseko (Author), Kumiko Kitta (Author), Kiyotaka Hoshiai (Author), Koki Chiba (Author), Kentaro Ando (Author), Yasuki Akie (Author), Atsuhiko T. Naito (Author), Atsushi Sugiyama (Author)
• Format: Book
• Published: Elsevier, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although azithromycin can suppress cardiac INa, IKr, IKs, ICa,L and IK1, its onset mechanisms for cardiovascular death have not been fully investigated. We examined electropharmacological effects of azithromycin in intravenous doses of 0.3, 3 and 30 mg/kg using microminipigs under the halothane anes...