Inhibition by Pregnenolone Sulphate, a Metabolite of the Neurosteroid Pregnenolone, of Voltage-Gated Sodium Channels Expressed in Xenopus Oocytes

• Główni autorzy: Takafumi Horishita (Autor), Susumu Ueno (Autor), Nobuyuki Yanagihara (Autor), Yuka Sudo (Autor), Yasuhito Uezono (Autor), Dan Okura (Autor), Takeyoshi Sata (Autor)
• Format: Książka
• Wydane: Elsevier, 2012-01-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Neurosteroids are known as allosteric modulators of the ligand-gated ion channel superfamily. Voltage-gated sodium channels (Nav) play an important role in mediating excitotoxic damages. Here we report the effects of neurosteroids on the function of Nav, using voltage-clamp techniques in Xenopus ooc...