Modern Approaches to the Management of Children with Hypophosphatasia

• Main Authors: Aleksander A. Baranov (Author), Tatiana T. Batysheva (Author), Olga V. Bykova (Author), Nato D. Vashakmadze (Author), Elena V. Vislobokova (Author), Alisa V. Vitebskaya (Author), Elena A. Vishneva (Author), Victoria Yu. Voynova (Author), Natalia V. Zhurkova (Author), Ekaterina Yu. Zakharova (Author), Larisa P. Kisel'nikova (Author), Mikhail M. Kostik (Author), Sergey I. Kutsev (Author), Tea V. Margieva (Author), Leyla S. Namazova-Baranova (Author), Svetlana V. Mikhaylova (Author), Sergey V. Moiseev (Author), Tatyana S. Nagornaya (Author), Liliia R. Selimzyanova (Author), Alla N. Semyachkina (Author), Olga Ya. Smirnova (Author), Marina V. Fedoseenko (Author), Svetlana V. Pishchal'nikova (Author)
• Format: Book
• Published: Union of pediatricians of Russia, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypophosphatasia is rare genetic disease caused by tissue-nonspecific alkaline phosphatase deficiency due to the mutation in the ALPL gene. Disease can manifest in utero, in childhood or in adults depending on its form and severity. This article presents modern data on the epidemiology, etiology, an...