Network model‐based screen for FDA‐approved drugs affecting cardiac fibrosis

• Hauptverfasser: Angela C. Zeigler (Verfasst von), Anirudha S. Chandrabhatla (Verfasst von), Steven L. Christiansen (Verfasst von), Anders R. Nelson (Verfasst von), Jeffrey W. Holmes (Verfasst von), Jeffrey J. Saucerman (Verfasst von)
• Format: Buch
• Veröffentlicht: Wiley, 2021-04-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Abstract Cardiac fibrosis is a significant component of pathological heart remodeling, yet it is not directly targeted by existing drugs. Systems pharmacology approaches have the potential to provide mechanistic frameworks with which to predict and understand how drugs modulate biological systems. H...