Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage

• Main Authors: Yingying Gong (Author), Meilin Wei (Author), Xiaopei Cao (Author), Changliu Xu (Author), Jiewen Jin (Author), Ling Pei (Author), Yanbing Li (Author), Haipeng Xiao (Author), Liting Wu (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diabetes, a global epidemic, is the leading cause of mortality globally. The aim of this study is to get better understanding of pathophysiology of diabetes. Methods Palmitic acid (PA)-treated β-cells, db/db mice and high fat diet (HFD)-fed mouse model of type 2 diabetes were est...