Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced β-cell damage

• Egile Nagusiak: Yingying Gong (Egilea), Meilin Wei (Egilea), Xiaopei Cao (Egilea), Changliu Xu (Egilea), Jiewen Jin (Egilea), Ling Pei (Egilea), Yanbing Li (Egilea), Haipeng Xiao (Egilea), Liting Wu (Egilea)
• Formatua: Liburua
• Argitaratua: BMC, 2024-11-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abstract Background Diabetes, a global epidemic, is the leading cause of mortality globally. The aim of this study is to get better understanding of pathophysiology of diabetes. Methods Palmitic acid (PA)-treated β-cells, db/db mice and high fat diet (HFD)-fed mouse model of type 2 diabetes were est...