Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments

• Main Authors: Jonatan Dewulf (Author), Ivanna Hrynchak (Author), Sarah Geudens (Author), Isabel Pintelon (Author), Christel Vangestel (Author), José Sereno (Author), Peter A. van Dam (Author), Antero J. Abrunhosa (Author), Filipe Elvas (Author), Tim Van den Wyngaert (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific antibody denosumab, [⁸⁹Zr]Zr...