Use of physiologically‐based pharmacokinetic modeling to inform dosing of the opioid analgesics fentanyl and methadone in children with obesity

• Main Authors: Jacqueline G. Gerhart (Author), Fernando O. Carreño (Author), Jennifer L. Ford (Author), Andrea N. Edginton (Author), Eliana M. Perrin (Author), Kevin M. Watt (Author), William J. Muller (Author), Andrew M. Atz (Author), Amira Al‐Uzri (Author), Paula Delmore (Author), Daniel Gonzalez (Author), Best Pharmaceuticals for Children Act-Pediatric Trials Network Steering Committee (Author)
• Format: Book
• Published: Wiley, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Obesity is an increasingly alarming public health threat, with nearly 20% of children classified as obese in the United States today. Children with obesity are commonly prescribed the opioids fentanyl and methadone, and accurate dosing is critical to reducing the risk of serious adverse eve...