Design and evaluation of rufinamide nanocrystals loaded thermoresponsive nasal in situ gelling system for improved drug distribution to brain

Rufinamide (Rufi) is an antiepileptic drug used to manage Lennox-Gastaut Syndrome and partial seizures. The oral bioavailability of Rufi is less due to its poor solubility and low dissolution rate in the gastrointestinal fluids. This results in less amount of drug reaching the brain following the or...

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Main Authors: Avantika Dalvi (Author), Punna Rao Ravi (Author), Chandra Teja Uppuluri (Author)
Format: Book
Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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