STC3141 improves acute lung injury through neutralizing circulating histone in rat with experimentally-induced acute respiratory distress syndrome

• Main Authors: Yangyang Ge (Author), Chenchen Wang (Author), Chenye Yao (Author), Yong Wang (Author), Yuduo Zheng (Author), Junjie Luo (Author), Jiayi Chen (Author), Yu Wang (Author), Fuquan Wang (Author), Li Wang (Author), Yun Lin (Author), Lin Shi (Author), Shanglong Yao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Acute respiratory distress syndrome (ARDS) remains a challenge because of its high morbidity and mortality. Circulation histones levels in ARDS patients were correlated to disease severity and mortality. This study examined the impact of histone neutralization in a rat model of acute lun...