Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

• Main Authors: Wei Lan (Author), Hong Ping Zhang (Author), Ying Wang (Author), Min Jiang (Author), Qian Li (Author), Dongqing An (Author)
• Format: Book
• Published: Bangladesh Pharmacological Society, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The purpose of this study was to investigate the antihypertensive mecha-nisms of piperitenone oxide in spontaneously hypertensive rat (SHR). Compared to control SHR, piperitenone oxide reduced the systolic blood pressure and serum endothelium-1 (ET-1). The nitric oxide (NO) production and ET-1 secre...