Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma

• Main Authors: Shengming Xu (Author), Haifeng Wang (Author), Yu Zhu (Author), Yong Han (Author), Liu Liu (Author), Xiangkai Zhang (Author), Jingzhou Hu (Author), Wuchang Zhang (Author), Shengzhong Duan (Author), Jiong Deng (Author), Zhiyuan Zhang (Author), Shuli Liu (Author)
• Format: Book
• Published: Nature Publishing Group, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and promote tumor progression in head and neck squamous cell carcinoma (HNSCC). However, the mechanisms underlying EREG dysregulation remain largely unknown. Here, we showed that dysregulated EREG was highly...