Mast Cell-Mediated Inhibition of Abdominal Neutrophil Inflammation by a PEGylated TLR7 Ligand

• Main Authors: Tomoko Hayashi (Author), Shiyin Yao (Author), Brian Crain (Author), Michael Chan (Author), Howard B. Cottam (Author), Fitzgerald Lao (Author), Dennis A. Carson (Author), Maripat Corr (Author)
• Format: Book
• Published: Hindawi Limited, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although the mechanisms for sustained chemokine gradients and recurring cell infiltration in sterile peritonitis have not been elucidated, toll-like receptors (TLRs) have been implicated. To abate the deleterious recruitment of neutrophils in sterile inflammation, we repeatedly administered a TLR7 l...