Icariin improves testicular dysfunction via enhancing proliferation and inhibiting mitochondria-dependent apoptosis pathway in high-fat diet and streptozotocin-induced diabetic rats

• Main Authors: Weiguo He (Author), Huiqing Liu (Author), Linlin Hu (Author), Yaohui Wang (Author), Lane Huang (Author), Aihong Liang (Author), Xuan Wang (Author), Qing Zhang (Author), Yi Chen (Author), Yi Cao (Author), Suyun Li (Author), Junli Wang (Author), Xiaocan Lei (Author)
• Format: Book
• Published: BMC, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Diabetes mellitus (DM), a chronic metabolic disease, severely impairs male reproductive function. However, the underpinning mechanisms are still incompletely defined, and there are no effective strategies or medicines for these reproductive lesions. Icariin (ICA), the main active...