Inhibition of Chloride Intracellular Channel 1 (CLIC1) as Biguanide Class-Effect to Impair Human Glioblastoma Stem Cell Viability

• Hoofdauteurs: Federica Barbieri (Auteur), Roberto Würth (Auteur), Alessandra Pattarozzi (Auteur), Ivan Verduci (Auteur), Chiara Mazzola (Auteur), Maria G. Cattaneo (Auteur), Michele Tonelli (Auteur), Agnese Solari (Auteur), Adriana Bajetto (Auteur), Antonio Daga (Auteur), Lucia M. Vicentini (Auteur), Michele Mazzanti (Auteur), Tullio Florio (Auteur)
• Formaat: Boek
• Gepubliceerd in: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The antidiabetic biguanide metformin exerts antiproliferative effects in different solid tumors. However, during preclinical studies, metformin concentrations required to induce cell growth arrest were invariably within the mM range, thus difficult to translate in a clinical setting. Consequently, t...