Sodium Dichloroacetate Pharmacological Effect as Related to Na-K-2Cl Cotransporter Inhibition in Rats

• Main Authors: Jūratė Stanevičiūtė (Author), Milda Juknevičienė (Author), Jolita Palubinskienė (Author), Ingrida Balnytė (Author), Angelija Valančiūtė (Author), Rūta Vosyliūtė (Author), Kęstutis Sužiedėlis (Author), Vaiva Lesauskaitė (Author), Donatas Stakišaitis (Author)
• Format: Book
• Published: SAGE Publishing, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The study objective was to investigate a possible sodium dichloroacetate (DCA) pharmacological mechanism causing an increase in diuresis in rats. The aim was to define characteristics of 24-hour urinary Na + , K + , Cl − , Ca 2+ , and Mg 2+ excretion in Wistar male rats and to evaluate effect of a s...