Functionally inactivated dominant viral antigens of human cytomegalovirus delivered in replication incompetent adenovirus type 6 vectors as vaccine candidates

• Main Authors: Aimin Tang (Author), Daniel C. Freed (Author), Fengsheng Li (Author), Steve Meschino (Author), Michael Prokop (Author), Andrew Bett (Author), Danilo Casimiro (Author), Dai Wang (Author), Tong-Ming Fu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

T cell immunity is critical in controlling human cytomegalovirus (HCMV) infection in transplant recipients, and T cells targeting viral immediate early proteins such as IE1, IE2 and pp65 have been speculated to be more effective against reactivation. Here we report efforts to construct replication i...